Technology Review - Published By MIT
Log in to My.TechnologyReview.com | Register
Advertisement
 

Insights, opinions, and our editors' analysis of the latest in emerging technologies.

Add RSS Feed XML

Stem Cells from a Human-Pig Hybrid

Scientists hope to create a cell model to study heart disease.
Wednesday, July 02, 2008
By Emily Singer

British scientists will use pig eggs and DNA from a human patient with heart disease to generate stem cells. If successful, these will be the first human stem cells made from animal eggs.

A shortage of human eggs--a central ingredient in the cloning process--has stalled human cloning, so scientists are studying whether animal eggs can do the trick. (Two groups in the United Kingdom have already been given permission to move forward with hybrid research.) The concept of human-animal hybrids has proved controversial, but scientists will only generate cells from the research; they won't let the embryos develop.

According to an article in the Guardian,

Although the stem cells will not contain any animal DNA, they will not be suitable for treating humans directly. Instead, the scientists will use the cells to learn how genetic mutations cause heart cells to malfunction and ultimately cause life-threatening cardiomyopathy.

"Ultimately they will help us understand where some of the problems associated with these diseases arise, and they could also provide models for the pharmaceutical industry to test new drugs," [Warwick Medical School scientist Justin] St John says. "We will effectively be creating and studying these diseases in a dish, but it's important to say that we're at the very early stages of this research and it will take a considerable amount of time."

Human-animal hybrid research has received much more attention in the United Kingdom than in the United States, largely because the research there is governed by a central regulatory board, and details of research proposals are made public. No broad-arching regulation exists in the United States, where scientists are mainly accountable to university ethical review boards.

Comments

  • Don't worry... we'll kill them when we're done
    robin26 on 07/18/2008 at 9:51 AM
    Posts:
    8
    Avg Rating:
    3/5
    "The concept of human-animal hybrids has proved controversial, but scientists will only generate cells from the research; they won't let the embryos develop."

    This somehow justifies producing, manipulating, and discarding human embryos (or hybrids thereof)? What makes it acceptable... that they're "not really human", or that "we'll kill them when we're done"?

    Progress in medical science does not justify (or even necessitate) treating human beings merely as objects for experimentation, to be used and discarded like so much raw material. Authentic science serves man without dehumanizing individual human beings.

    No, the ends do not justify the means, which in this case are not only "controversial" but deplorable.
    Rate this comment: 12345
    • Re: Don't worry... we'll kill them when we're done
      KurtC415@Gmail.com on 07/23/2008 at 8:59 PM
      Posts:
      1
      you obviously don't know anyone with a spinal cord injury such as myself.  I broke my neck in a car accident on August 18, 2004 at 9 a.m. I'm paralyzed from my armpits down.  I have been told by doctors that my spinal cord injury is "complete" C-5-6.

      Before my accident, I would have shared your sentiments towards this research.  I have supported animal research by providing infection control products such as disposable exam gloves, medical grade respirators, disposable clothing and a complete line of personal protective equipment to protect both the researchers and animals from infectious diseases, allergens and blood-borne pathogens.

      The United States has done a phenomenal job of researching cures for many debilitating diseases through animal research.  While all life is valuable, I feel that it is very important for us to realize that we are spiritual beings in physical bodies.  From this viewpoint we can see the spirit Of Infinite Mind/God manifesting and creating cures of the physical body for this time in our current state of evolution vis-à-vis Eckardt Tolle.
      Nameste,
      Kurt Christensen
      Rate this comment: 12345
      • Re: Don't worry... we'll kill them when we're done
        robin26 on 07/24/2008 at 9:37 AM
        Posts:
        8
        Avg Rating:
        3/5
        Kurt,

        You have my sympathy for the terrible injury You suffered, and its aftermath.  My cousin, just a couple years older than myself, has spent the past 30 years in a wheelchair, almost totally paralyzed by a motorcycle accident. 

        People with such injuries -and all people of good will- greatly desire to see advancements in medical science that may bring treatments or cures for such injuries.  I sincerely hope that You and my cousin may stand and walk again, someday.

        Yet such good and noble desires can not justify using other human beings -preembryonic or otherwise- as raw material for scientific experimentation.  Let research proceed along other lines that respect the dignity of every human individual at every stage of development.

        Volunteering oneself for participation in medical studies is one thing.  Subjecting the defenseless to devastating and irreversible procedures and then destroying them is inhuman. 

        It is indefensible that some humans should be destroyed for the benefit of others.
        Rate this comment: 12345

Video

Intensifying the Sun Jon Mapel, cofounder of Covalent Solar, explains how the solar-power company got its start and how its technology works.
35 Innovators under 35 Tesla Roadster* Mitch Kapor How Obama Really Did It Digging a Smarter Crowd
35 Innovators under 35
Tesla Roadster*
Mitch Kapor
How Obama Really Did It
Digging a Smarter Crowd
 
 
35 Innovators under 35
Advertisement

Current Issue

Technology Review September/October 2008
How Obama Really Did It
Social technology helped bring him to the brink of the presidency.
•  Subscribe
Save 41%
•  Table of Contents
•  MIT News

Magazine Services

Career Resources

MIT Technology Insider

Stories and breaking news from inside MIT about the latest research, innovations, and startups--in a convenient monthly e-newsletter. Subscribe today

Follow us on Twitter

Twitter

Get Technology Review updates via the web, cellphone, or Instant Messager – Follow techreview on Twitter!

Advertisement
Advertisement
Advertisement
Advertisement
Advertisement
MIT Massachusetts Institute of Technology